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HCMV Arizona Center on Aging

HCMV Arizona Center on Aging

They discovered that while over time more and more cells of the immune system – particularly the T cells, a type of white blood cell critical in the immune system’s response to infection – concentrate on CMV, the T cells in charge of responding to other viruses were fewer in numbers and functionally impaired. Similar conclusions were reached by another group from Germany, led by Dr. Urs Karrer, and are published in the same issue of PloS Pathogens.

“The ongoing presence of CMV contributes to the defects of the aged immune system, helping to explain why older adults often are more prone to infectious diseases than young people,” said Nikolich-Zugich. “Future studies will allow us to understand the effect of persisting CMV infections on immune responses, which particularly is important for the efficiency of vaccination strategies.”

This work was supported in part by the U.S. Public Health Service grants AG20719 and AG23664 from the National Institutes of Health to Nikolich-Zugich and by the Collins Medical Trust and by the HGF-NG-VH-638 grants to Čiin-Šain. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Contacts

Media Contact

Jean Spinelli Arizona Health Sciences Center 520-626-7301 jeans@ahsc.arizona.edu

Research Article

Cytomegalovirus Infection Impairs Immune Responses and Accentuates T-cell Pool Changes Observed in Mice with Aging

Luka Cicin-Sain mail,

* E-mail: luka.cicin-sain@helmholtz-hzi.de (LCS); nikolich@email.arizona.edu (JNZ)

Affiliations: Department of Vaccinology and Applied Microbiology, Helmholtz Center for Infection Research, Braunschweig, Germany, Vaccine and Gene Therapy Institute and the Oregon National Primate Research Center, Oregon Health and Science University, Portland, Oregon, United States of America

James D. Brien,

Affiliations: Vaccine and Gene Therapy Institute and the Oregon National Primate Research Center, Oregon Health and Science University, Portland, Oregon, United States of America, Department of Microbiology, Washington University School of Medicine, St. Louis, Missouri, United States of America

 

Jennifer L. Uhrlaub,

Affiliations: Vaccine and Gene Therapy Institute and the Oregon National Primate Research Center, Oregon Health and Science University, Portland, Oregon, United States of America, Department of Immunobiology and the Arizona Center on Aging, University of Arizona College of Medicine, Tucson, Arizona, United States of America

Anja Drabig,

Affiliation: Department of Vaccinology and Applied Microbiology, Helmholtz Center for Infection Research, Braunschweig, Germany

Thomas F. Marandu,

Affiliation: Department of Vaccinology and Applied Microbiology, Helmholtz Center for Infection Research, Braunschweig, Germany

Janko Nikolich-Zugich mail

* E-mail: luka.cicin-sain@helmholtz-hzi.de (LCS); nikolich@email.arizona.edu (JNZ)

Affiliations: Vaccine and Gene Therapy Institute and the Oregon National Primate Research Center, Oregon Health and Science University, Portland, Oregon, United States of America, Department of Immunobiology and the Arizona Center on Aging, University of Arizona College of Medicine, Tucson, Arizona, United States of America

 

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