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Espaço de publicação e discussão sobre oncologia. GBM IMMUNOTHERAPY ONCO-VIRUS ONCOLOGY CANCER CHEMOTHERAPY RADIOTHERAPY



Domingo, 26.07.15

CLINICAL TRIALS LISTING GBM ABTA

 

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Below is a list of the 439 clinical trials for Brain Tumor currently in our database.

Click Find a Match or call 1-877-769-4833 to see if these trials match your profile.

 
Title A Randomized Study of Nivolumab Versus Bevacizumab and a Safety Study of Nivolumab or Nivolumab Combined With Ipilimumab in Adult Subjects With Recurrent Glioblastoma (GBM) (CheckMate 143)  
Phase III  
Modality Immunotherapy (Monoclonal Antibody), Signal Transduction Inhibitor  
Sponsor Type Private
Title A Study Comparing Two Carboplatin Containing Regimens for Children and Young Adults With Previously Untreated Low Grade Glioma  
Phase III  
Modality Chemotherapy  
Sponsor Type Private
Title Armodafinil in Reducing Cancer-Related Fatigue in Patients With Glioblastoma Multiforme  
Phase III  
Modality Other  
Sponsor Type Government
Title Can Iron Lessen Anemia Due to Cancer and Chemotherapy: A Study to Investigate the Efficacy and Safety of Injectafer®  
Phase III  
Modality    
Sponsor Type Private
Title Extended Varenicline Treatment for Smoking Among Cancer Patients  
Phase III  
Modality Other, Supportive Care  
Sponsor Type Private
Title Fosaprepitant Dimeglumine in Preventing Chemotherapy-induced Nausea and Vomiting (MK-0517-031 AM3)  
Phase III  
Modality Hormonal Therapy, Supportive Care  
Sponsor Type Private
Title Long Term Chamomile Therapy for Anxiety  
Phase III  
Modality Supportive Care  
Sponsor Type Government
Title Maintenance Chemotherapy or Observation Following Induction Chemotherapy and Radiation Therapy in Treating Younger Patients With Newly Diagnosed Ependymoma  
Phase III  
Modality Chemotherapy, Radiation Therapy  
Sponsor Type Private
Title Placebo Controlled Double Blind Crossover Trial of Metformin for Brain Repair in Children With Cranial-Spinal Radiation for Medulloblastoma  
Phase III  
Modality Supportive Care  
Sponsor Type Private
Title Radiation Therapy With or Without Temozolomide in Treating Patients With Anaplastic Glioma  
Phase III  
Modality Chemotherapy, Radiation Therapy  
Sponsor Type Government

Autoria e outros dados (tags, etc)

por cyto às 18:26

Domingo, 26.07.15

Brain Tumor Treatments

 

Brain Tumor Treatments

 

Brain tumor treatment depends on a number of factors, including the type, location, size, and grade of the tumor, as well as the age and health of the patient. Your doctor can present your treatment options and tell you what to expect from each one.

 

Specialists who treat brain tumors include neurosurgeons, neurooncologists, medical oncologists, and radiation oncologists. In addition to the specialist, your treatment team may include other professionals such as a nurse, dietitian, mental health counselor, social worker, physical therapist, occupational therapist, and/or speech therapist.

 

Many people with brain tumors want to take an active part in making decisions about their medical care. They want to learn all they can about their disease and their treatment choices. Below are some questions you might want to ask your doctor:

  1. What type of brain tumor is it?
  2. Is it benign or malignant?
  3. What grade is my tumor?
  4. What are the treatment options? What do you recommend? Why?
  5. What are the benefits of each treatment option?
  6. What are the risks and possible side effects of each option?
  7. What is the treatment likely to cost?
  8. How will treatment affect my everyday activities?
  9. Should I participate in a clinical trial/research study? If so, which one?

It is not necessary to ask all of these questions or to understand the answers all at one time. There will be other opportunities to ask your doctor to explain things that are not clear and to ask for more information.

 

Before starting treatment, you may want a second opinion about your diagnosis and treatment plan. Some insurance companies require a second opinion; others may cover a second opinion if the patient or doctor requests it.

Autoria e outros dados (tags, etc)

por cyto às 18:23

Domingo, 26.07.15

Glioblastoma (GBM)

 

Glioblastoma (GBM)

 

Glioblastomas (GBM) are tumors that arise from astrocytes—the star-shaped cells that make up the “glue-like,” or supportive tissue of the brain. These tumors are usually highly malignant (cancerous) because the cells reproduce quickly and they are supported by a large network of blood vessels.

 

Location

Glioblastomas are generally found in the cerebral hemispheres of the brain, but can be found anywhere in the brain or spinal cord.

 

Description

Glioblastomas usually contain a mix of cell types. It is not unusual for these tumors to contain cystic mineral, calcium deposits, blood vessels, or a mixed grade of cells.

 

Glioblastomas are usually highly malignant—a large number of tumor cells are reproducing at any given time, and they are nourished by an ample blood supply. Dead cells may also be seen, especially toward the center of the tumor. Because these tumors come from normal brain cells, it is easy for them to invade and live within normal brain tissue. However, glioblastoma rarely spreads elsewhere in the body.

 

There are two types of glioblastomas:

  • Primary, or de novo: These tumors tend to form and make their presence known quickly. This is the most common form of glioblastoma; it is very aggressive.
  • Secondary: These tumors have a longer, somewhat slower growth history, but still are very aggressive. They may begin as lower-grade tumors which eventually become higher grade. They tend to be found in people 45 and younger, and represent about 10% of glioblastomas.

Symptoms

Because glioblastomas can grow rapidly, the most common symptoms are usually caused by increased pressure in the brain. These symptoms can include headache, nausea, vomiting, and drowsiness. Depending on the location of the tumor, patients can develop a variety of other symptoms such as weakness on one side of the body, memory and/or speech difficulties, and visual changes.

 

Incidence

This tumor represents about 15.4% of all primary brain tumors and about 60-75% of all astrocytomas. They increase in frequency with age, and affect more men than women. Only three percent of childhood brain tumors are glioblastomas.

 

Cause

Like many tumor types, the exact cause of glioblastoma is not known.

 

Treatment

Glioblastoma can be difficult to treat because the tumors contain so many different types of cells. Some cells may respond well to certain therapies, while others may not be affected at all. This is why the treatment plan for glioblastoma may combine several approaches.

 

The first step in treating glioblastoma is a procedure to make a diagnosis, relieve pressure on the brain, and safely remove as much tumor as possible through surgery. Because gliblastomas have finger-like tentacles, they are very difficult to completely remove. This is particularly true when they are growing near the parts of the brain that control important functions such as language and coordination.

 

Radiation and chemotherapy may be used to slow the growth of tumors that cannot be removed with surgery. Chemotherapy may also be used to delay the need for radiation in young children.

 

Learn more about different treatment options for brain tumors on our Treatment page.

 

Some glioblastoma treatments are available through research studies called clinical trials. Click here to access Trial ConnectTM, the ABTA's clinical trial matching service.

 

Prognosis

Prognosis is usually reported in years of "median survival." Median survival is the time at which an equal number of patients do better and an equal number of patients do worse. With standard treatment, median survival for adults with an anaplastic astrocytoma is about two to three years. For adults with more aggressive glioblastoma, treated with concurrent temozolamide and radiation therapy, median survival is about 14.6 months and two-year survival is 30%. However, a 2009 study reported that almost 10% of patients with glioblastoma may live five years or longer.

 

Children with high-grade tumors (grades III and IV) tend to do better than adults; five-year survival for children is about 25%.

 

In addition, glioblastoma patients who have had their MGMT gene shut off by a process called methylation also have prolonged survival rates. The MGMT gene is thought to be a significant predictor of response.

 

However, not all glioblastomas have the same biologic abnormalities. This may be the reason different patients respond differently to the same treatment and why different patients with the same tumor have different outcomes. Researchers continue to study the common characteristics of long-term brain tumor survivors, and how personalized and targeted treatments may be optimally used to treat brain tumor patients.

 

Emerging Biomarkers in Glioblastoma

There are a number of biomarkers, or molecular signatures, which have the potential to contribute to diagnosis, prognosis and prediction of response to therapy in glioblastoma. Click here to read more about emerging biomarkersand their impact on future therapies

Autoria e outros dados (tags, etc)

por cyto às 18:20


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